Position available Postdoctoral Fellow (PDF)
Principal Investigator Dr. Virupakshi Soppina
Location Indian Institute of Technology Gandhinagar
Discipline Biological Engineering
Duration 1 year (can be extendable for TWO more years based on the performance)
Email application
material to
vsoppina@iitgn.ac.in (single PDF file please)
Application deadline 30th April 2017
Broad area Intracellular transport and human diseases
Specialization My lab requires extremely interested, scientifically motivated and humble postdoc with good writing and verbal communicated skills. Strong experimental background in cell biology, biochemistry (protein handling, purification), molecular biology and some microscopy knowledge.
Specialization My lab requires extremely interested, scientifically motivated and humble postdoc with good writing and verbal communicated skills. Strong experimental background in cell biology, biochemistry (protein handling, purification), molecular biology and some microscopy knowledge.
Minimum
Qualification
Ph.D in Biology or related area
Research Description
Our lab is interested in understanding the cytoskeletal systems and their roles in intracellular
trafficking in mammalian cells. Molecular motors of the kinesin and dynein families are
mechanochemical enzymes that convert the chemical energy derived from ATP hydrolysis to
mechanical energy to generate force and motion along microtubule tracks to carry cargoes (e.g.
proteins, mRNA, vesicles, endosomes) towards the plus (kinesins) and minus ends (dyneins) of the
microtubules, a process termed "intracellular transport".
Research at IITGN is focused on major cellular and neuronal transporter of kinesin-3 family
motors. In particular, I am passionately interested in understanding the molecular mechanisms of
kinesin-3 based neuronal cargo trafficking, regulation and their physiological significance. The
mammalian kinesin-3 family is one of the largest of the kinesin superfamily and consists of five
subfamilies. Kinesin-3 motors have been found to play important roles across species in
intracellular and neuronal transport, development, cell signaling, and cytokinesis.
Defects in
kinesin-3 transport have been implicated in diverse genetic, developmental, neurodegenerative and
cancer diseases. Despite their widespread functions and clinical importance, the mechanisms of
kinesin-3 mediated intracellular transport, regulations and their deficiencies in the context of
human diseases are largely unknown.
The project will continue to investigating the members of this family at cellular, molecular,
structural and single molecule level to gain fundamental insights into molecular mechanisms of
neuronal transport systems and the implications for various neurodegenerative diseases caused by
the defects in microtubule based transport system. We will use cultured hippocampal neurons and
Caenorhabditis elegans as model systems.
Interested candidates may send a ‘one page letter of motivation, complete CV, list of publications,
one page summary of doctoral research and one page future research proposal based on above
research description and PI’s publications’ to the Principal Investigator (vsoppina@iitgn.ac.in).
Please also arrange for three letters of recommendation to the email address vsoppina@iitgn.ac.in (no
need to send any hard copy). Any kind of queries related to this position may be directed to
Dr. Virupakshi Soppina (vsoppina@iitgn.ac.in).
Don't forget to mention helpBIOTECH when you Apply
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