Junior Research Fellow (JRF) under the following research project
funded by the Science and Engineering Research Board (SERB),
Department of Science and Technology (DST), Government of India.
Title of the project “Molecular Mechanisms of Kinesin-3 Autoregulation and Their
Biophysical Measurements”
Principal Investigator Dr. Virupakshi Soppina
Location Indian Institute of Technology Gandhinagar
Discipline Biological Engineering
Duration Initial appointment for one year, extendable one more year based on
performance
Email application
material to
vsoppina@iitgn.ac.in (single PDF file please)
Minimum eligibility First class M.Sc. or M.Tech degree in any discipline of Life Science from a
recognized University/Institute.
Candidate should have valid CSIR NET /
UGC or GATE or equivalent fellowship. An aptitude for learning new
techniques is a must.
Application deadline 25th December 2017
Broad area Intracellular transport system and their regulations
Research Description:
Our lab is interested in understanding the cytoskeletal systems and their roles in intracellular
trafficking in mammalian cells. Molecular motors of the kinesin and dynein families are
mechanochemical enzymes that convert the chemical energy derived from ATP hydrolysis to
mechanical energy to generate force and motion along microtubule tracks to carry cargoes (e.g.
proteins, mRNA, vesicles, endosomes) towards the plus (kinesins) and minus ends (dyneins) of the
microtubules, a process termed "intracellular transport".
My research at IITGN is focused on major cellular and neuronal transporter of kinesin-3 family
motors. In particular, I am passionately interested in understanding the molecular mechanisms of
kinesin-3 based neuronal cargo trafficking, regulation and their physiological significance. The
mammalian kinesin-3 family is one of the largest of the kinesin superfamily and consists of five
subfamilies. Kinesin-3 motors have been found to play important roles across species in
intracellular and neuronal transport, development, cell signaling, and cytokinesis. Defects in
kinesin-3 transport have been implicated in diverse genetic, developmental, neurodegenerative and
cancer diseases. Despite their widespread functions and clinical importance, the mechanisms of
kinesin-3 mediated intracellular transport, regulations and their deficiencies in the context of
human diseases are largely unknown.
Interested candidates may please send a CV and one page write-up of your research interest in general
and/or specific to our lab to Dr. Virupakshi Soppina (vsoppina@iitgn.ac.in). Any kind of queries
related to this position may be directed to Dr. Virupakshi Soppina (vsoppina@iitgn.ac.in).
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