DR. REDDY’S INSTITUTE OF LIFE
SCIENCES,
HYDERABAD
PROJECT TITLE
Identification of the mechanistic basis of early striatal damage in Glutaric Aciduria
Type I
FUNDING AGENCY:
DBT
POSITION:
Junior Research Fellow with any one of the following:
-
Post Graduate Degree in Professional Course (M.Pharm, M.Tech. Biotechnology or
similar)
- Post Graduate Degree in Basic Science with NET qualification (M.Sc.
Biochemistry/Biotechnology/Genetics/Molecular Biology etc)
NETs accepted: CSIR-NET including LS; GATE, JAM, GPAT, BET, JEST, JGEEBILS, ICMR-JRF
and ICAR- AICE
Candidates with experience handling Zebrafish, prior hands-on experience with molecular
Biology, biochemistry or microbiology techniques are preferred.
A possibility of Ph.D
enrollment exists, however it is not guaranteed.
EMOLUMENTS AND DURATION
Rs. 25000+HRA per month
Project duration: 3 years. Appointment will be renewed yearly contingent on performance.
DEADLINE:
15th August, 2018
PROJECT SUMMARY
Glutaric aciduria type I (GA1) is an autosomal recessive IEM (Inborn errors of metabolism) disorder that arises
due to mutations in the enzyme Glutaryl Co-A dehydrogenase (GCDH), and is found to occur with high
frequency (~1:5000)certain ethnic groups including the states of AP and Telangana, India.
Children with GA1 usually present with macrocephaly at birth, and a trigger such as fever or infection in early
childhood results in acute encephalopathic crises and striatal damage, leading to severe dystonia and
dyskinesis. There is so far, no way to predict the susceptibility to striatal damage or prevent it, especially in the
presymptomatic stages. We hypothesize that imbalance in molecular pathways in GA1 patients in the gestation
or newborn stages, could predispose some patients to such striatal damage and our objective is to use a larval
zebrafish model of GA1 to identify such molecular changes. A larval zebrafish model will allow access to a
developmental window that is inaccessible in mice or others thus making this a necessary and sufficient tool
to investigate the mechanistic basis of early striatal damage and contribute to new targets and therapeutic
strategies..
Qualified and interested candidates may send their curriculum vitae by e-mail to
hr@drils.org on or before deadline mention in the subject line of the mail the following code:
- GA1- Biology, Selected candidates will be called for a personal interview to Dr. Reddy’s
Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad.
Candidates will not be reimbursed for Travel for the Interview, if short listed.
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