Bose Biophysics/Biochemistry Project Vacancies

BOSE INSTITUTE
P-1/12,
C.I.T. Scheme VII-M, Kankurgachi
KOLKATA

RECRUITMENT OF 2 JUNIOR (INSTITUTE) RESEARCH SCHOLAR

Tenable in the Department of Chemistry under Institutional Programmes –

(i) Structure, Function and Engineering Protein and

(ii) Development of Systems Biology

i. FOR POSITION –1

ESSENTIAL A good M Sc Physics / Chemistry / Biochemistry /Biophysics with NET / GATE qualifications / other discipline interested in doing research work in interdisciplinary topic.

DESIRABLE Knowledge of chemical kinetics differential equation, molecular biology, biochemistry and/or molecular genetics is desirable. The applicant with
Knowledge of nonlinear dynamics will be given preference.

BRIEF DRESCRIPTION OF WORK Eukaryotic cells respond to the changes made in the environment through the activation of their signaling pathways. Mitogen Activated Protein Kinase (MAPK) pathway is one of them. In our dry lab we plan to model and study MAPK pathways in eukaryotic cell based on the existing experimental results to understand the signaling cascade in details

ii. FOR POSITION –2

ESSENTIAL A good M. Sc. in Biochemistry / Biophysics /Biotechnology or any relevant subject with NET / GATE qualifications.

DESIRABLE Candidates having B.Sc. level knowledge of Physics and Chemistry is desirable.

BRIEF DRESCRIPTION OF WORK Transcription is the first step in gene expression where most regulation occurs. RNAP core enzyme together with sigma factors and numerous regulators orchestrates the gene expression in bacteria. Our lab seeks to characterize the interactions among RNAP, sigma factors, and regulators required for various gene expressions in Mycobacterium tuberculosis. The proposed work will use integrated biophysical, biochemical and genetic approaches, along with a recombinant in vitro transcription system to address two specific aims :
A. Determine the role of alternative sigma factors in gene regulation of M. tuberculosis.
B. Identify and characterize inhibitors of M. tuberculosis gene expression.

FELLOWSHIP : Rs. 12,000/- p.m., plus admissible HRA and Medical benefit.

Last date for receipt of application is 2nd July 2009.

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