PhD Position, Aberrant mRNA Splicing in Disease
Job description:
The posttranscriptional processing research group at the Department of Biochemistry and Molecular Biology, the University of Southern Denmark, invites applications for a PhD position within the field of miss-regulated pre-mRNA splicing and disease. The position is to be filled from 1 January, 2012 or soon thereafter.
The project is focused on how inherited mutations can cause aberrant splicing and human disease, with special focus on identification and characterization of splicing regulatory motifs important for metabolic and neuromuscular diseases. Both patient cells, model- and reporter-minigenes are used to explore changes in mRNA splicing pattern and to identify the involved splicing regulatory proteins. More specifically the project aims at identification and characterization of global binding sites for splicing regulatory proteins employing Next Generation Sequencing of RNA.
Applications are sought from candidates with a master degree in molecular biology, biochemistry, cell biology, medicine or a related field and documented experience in molecular and cellular biology. In particular experimental expertise in RNA biology, Next Generation Sequencing and bioinformatics is preferable. Applicants should have demonstrated scientific productivity, good inter-personal and communication skills, and be able to conduct independent and creative research.
The Department of Biochemistry and Molecular Biology offers a strong, international and competitive research environment within the fields of molecular genetics and cell biology, protein chemistry and mass spectrometry, molecular microbiology and biophysics.
For further information about the position please contact Professor Brage Storstein Andresen, PhD, e-mail: bragea@bmb.sdu.dk, phone: +45 6550 2413.
Application, salary, etc.:
Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
The successful applicant will be employed in accordance with the agreement of 1 October 2008 on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations).
The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).
The university encourages all persons interested in the position to apply, regardless of their age, gender, religious affiliation or ethnic background.
Application must be made in the form of a Declaration of Interest including the following:
• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages)
• Detailed CV, including personal contact information
• Certified copy of diploma
• At least two reference letters, signed
All applications should be marked: “Job ID 113027”.
Further information about the PhD-study can be found at the homepage of the University.
Applications must be forwarded by e-mail (in Adobe PDF format alternatively Word 2003 or newer format) to sciencejobs@sdu.dk.
Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.
Closing date 7 December, 2011 at 12 noon
Further Info: http://www.jobs.sdu.dk/vis_stilling.php?id=6907&lang=eng
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