The Systems and Cell Biology of Neurodegeneration Lab, at the Medical Faculty of University of Zurich is recruiting a highly motivated Postdoctoral Scientist.
Neurodegenerative diseases are complex whose etiologies cannot be pinned to few genes. In the case of late onset Alzheimer’s disease (AD) and Parkinson’s disease, the identity of the risk genes is still not known. By combining functional genomics with computational tools, we intend to understand the complex molecular network that underlies AD. The lab uses state of the art high-throughput screening methods and cell biological tools to identify genes involved in these diseases and in parallel, also characterize the mechanism by which they regulate this process (Rajendran, et al, Science, 2008; Rajendran, et al, PNAS, 2006, Aguzzi & Rajendran, Neuron, 2009, Rajendran, et al, Nature Rev. Drug Discovery, 2010).
Through an RNAi based screen, we have identified interesting hits that regulate the production of β-amyloid peptide, a molecule causatively linked to Alzheimer’s disease. The project involves studying the molecular networks and modeling the complexity involved in Alzheimer’s disease.
Candidates should have their PhDs in Bioinformatics or an equivalent area. Candidates should be able to demonstrate a track record of independent productive research, have strong organizational, written, and verbal skills and be able to work both independently and as part of a laboratory team. Only candidates who have abundant experience in systems biology/ network biology tools need apply.
Interested candidates are encouraged to apply with their CV, representative publications and two or three references to Prof. Lawrence Rajendran: rajendran@physik.uzh.ch, latest by 5th November 2012.
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