National Institute of Pathology (ICMR)
Workshop on Electron Microscopy for Diagnostics & Biomedical Research
September 23 to 27, 2013
The National Institute of Pathology (NIP) is one of the premier research Institutes of Indian Council of Medical Research (ICMR) and has infrastructure and expertise in various aspects of “Modern Technologies” such as genomics, proteomics, immunology, structural and stem cell biology etc. ‘Electron Microscopy’ through visualization of sub-cellular structures constitutes a key component of diagnostic armament available to pathologists.
With possibilities of studying sub-cellular localization of constituent chemical elements, X-ray diffraction patterns along with ultra-structure of cells and organelles in biological tissues it serves as a modern tool in understanding the “Structure – Function relationship”.
The appropriate use of ultrastructural study adds a new dimension to diagnostic pathology. The transmission electron microscope (TEM) uses electrons to image tissues at much greater magnification than is possible using photons in a light microscope, allowing us to visualize in detail the many structures and organelles within cells.
After the first TEM description of a neoplastic cell in a rat by Porter and Thompson in 1947, electron microscopy has proven useful in the evaluation of several neoplastic and non-neoplastic human diseases, viz., myopathies, viral infections and glomerulonephritides, . Accordingly electron microscopy has a strategic position in the diagnosis of tumours, neuromuscular, ciliary, storage and renal disorders. Indeed, the latter conditions now account for the great bulk of cases for which ultra-structural studies are currently requisitioned.
While the advances in Immunohistochemistry have led to reduced dependence on electron microscope for diagnosis in several conditions, EM still plays a decisive role for nephritic syndrome, certain tumours and bullous disorders. Hence, it is important for diagnostic pathologists to acquire the skills of electron microscopy for specific diagnostic needs as well as to carry out various research activities.
There is an urgent need for training research faculty and students from both medical and bio-medical fields in usage this state of the art characterizing tool and proper interpretation the morphological changes.
Current workshop is a step in this direction. The focus of this workshop is on training in sample collection and preparation methodology on one hand and correct usage of TEM and interpretation of ultra-structural morphology on the other. The workshop will be conducted by leading and well experienced authorities in Electron Microscopy. The course will be conducted through lectures, practical demonstrations and hands on training with an aim to make young researchers knowledgeable enough to add purpose to their characterization work.
On behalf of the ICMR and NIP, New Delhi, it is my great pleasure to welcome those who are interested to attend this workshop.
Dr. Sunita Saxena,
Director, National Institute of Pathology
Chairperson, Organizing Committee
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