Post : Project Scientist III
Qualification : PhD with minimum 5 years postdoctoral experience in Bioinformatics and Immunoinformatics with first author publications or significant and defined role in joint publications
No. of Vacancy : One
Language : English, Kannada,
Location : Bangalore, Karnataka
Application due date : 22nd December, 2021
Salary : Rs. 78,000+24%HRA
Brief Description about the Project:
IMPORTANCE Proposal Hypothesis: Variation in innate immune activation and attendant cardiac damage and dysfunction collectively drive systemic immunopathology and account for the differences in COVID-19 mortality between SAs in the UK and India. Specific Aims to Address this Hypothesis 1. Assess the differences in pre-existing health conditions, disease severity and the pattern of in-hospital complications between SAs admitted with COVID-19 in the UK versus India to determine the contribution of pre-existing CVD/diabetes and cardiac dysfunction. Approach: Retrospective analyses of existing clinical and imaging datasets in both countries. 2. Determine whether there are inherent differences in microbially-induced proinflammatory and antiviral immune responses between SAs in UK versus India, and their association with CVD and autoantibodies to IFN. Approach; Study of non-infected subjects with a range of CV risk factors. 3. Perform extensive systemic immunophenotyping, and analysis of endothelial, complement activation, and cardiac function in SAs admitted with severe COVID-19 in London and India to identify key immune patterns / signatures associated with clinical outcome. Approach: Prospective study in patients hospitalised with severe COVID-19. 4. Determine the inter-relationship between immune responses, pre-existing CVD and functional outcome in SAs who have recovered from COVID19 in the UK versus India. Approach: Add-on analyses in recovered COVID-19 patients being monitored at 6-9 months post-discharge.
Key Skills
- The ability to undertake high end Bioinformatic analysis and data interpret immune functional data derived by RNA Sequence Analysis of bulk immune cells; single cell transcriptome analysis; CHIP-Seq analysis; SNP analysis and T cell and B cell repertoire analysis
- Ability to work independently and be collegiate within a wider team of immunologists.
- Evidence of demonstrable scientific leadership skills with first author publications in field of research with impact and keenness to progress towards an independent researcher status.
- Ability to communicate and interpret scientific literature and primary data using a variety of appropriate software
- Evidence of having undertaken scientific administrative duties including ordering consumables, awareness of financial records and supervising junior staff
Core Responsibilities:
- To conduct primary research as per the CARDINNATE award in the context of Bioinformatic analysis of immune data
- To manage junior staff appointed to the project in conjunction with the PI
- To undertake key scientific administrative duties in placing ordering and maintaining an overview of expenditure
- To communicate work plan and data in weekly scientific laboratory meetings
- To undertake scholarly research activities such as scientific literature analysis to keep abreast of the current field and to effectively communicate academic thinking
Specific Activities
- To plan, set up and execute scientific data analysis in conjunction with discussions with the PI
- To train support staff
- To undertake forward thinking research plans through literature analysis and to test fresh hypothesis.
- To place orders for consumables and maintain records of finance expenditure
- To effectively communicate with staff members of the wider department at SJRI and provide an oversight of the overall science
To Apply : E-mail cover letter, CV, the names & contact details of Referees
To yashashwini@sjri.res.in cc hr@sjri.res.in
For more information please visit our website www.sjri.res.in
Can Contact us on the following Numbers 080-49467010/49467011
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