'The Organ Mechanobiology lab at NCBS-TIFR is seeking passionate and motivated PhD/Postdoc candidates interested in exploring a research career at the interface of cell biology, developmental biology, and tissue mechanics.
Our lab uses C. elegans as a model to study how mechanical forces and biochemical signals guide organ morphogenesis and function. We employ interdisciplinary approaches, including tissue-specific genetic manipulations, CRISPR-based knock-in/out techniques, quantitative live imaging, transcriptomics, and biophysical methods such as laser ablations, optogenetics, and microfluidics for high-throughput, long-term imaging. For more details visit our website. A few specific questions we are exploring in the lab includes:
What is the role of mechanical force in defining cell shape and tissue architecture during organ development and homeostasis?
How do mechanics influence germ cell fate specification during gametogenesis?
How does the mechanical microenvironment defined by the extracellular matrix affect organ morphogenesis?
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