Advertisement No.: NIBMG/ ACAD/PROJECT RECT./2026-27/084 Date: 15 - 06 -2026
Position available
BRIC-National Institute of Biomedical Genomics (NIBMG) Kalyani is an Institute of Government of India,
Ministry of Science & Technology, Department of Biotechnology. The Institute has created the necessary
physical infrastructure and critical platform technologies to support research, translation and training in
biomedical genomics.
Applications are invited for the position of Project Linked Person (Project Associate-I, PA-I) for
extramural project to be executed by the BRIC-National institute of Biomedical Genomics, Kalyani.
Selected applicants will be appointed initially for one year. The tenure of appointment may be
extended depending on performance and availability of funds.
Project Name: Investigating the role of Arid1a in chromatin organization: Potential translation to
cancer therapy
Principal Investigator’s name: Dr. Sriram Sridharan
Research Description: Genome instability is a “enabling hallmark of cancer” which can drive
activation of the other hallmarks of cancer. Cellular maintenance includes a plethora of
endogenous processes including DNA replication, transcription and chromatin organization.
Several endogenous and exogenous disruptions frequently interfere with these cellular
maintenance processes which need to be counteracted effectively to maintain the integrity of the
genome. For this, mammalian systems have developed multiple pathways to counteract replication
stress and DNA damage collectively known as the DNA damage response (DDR) pathways.
However, the same pathways that normal cells utilize to maintain genome integrity in the face of
these damages are also available to cancer cells to help overcome and survive elevated levels of
DNA damage, replication stress and therapeutic intervention. Thus, understanding the genomic
contexts that induce DNA damage and mechanisms utilized by cells to overcome this stress is very
important in understanding cancer aetiology and designing effective therapeutic regimen.
SWI/SNF chromatin remodelling factors are a family of ATP-dependent chromatin remodelling
complexes that are critical for nucleosomal rearrangements thus allowing for regulation of gene
expression. Arid1a is a subunit of this family of proteins, has been shown to have critical roles in
regulation of DNA Damage Response (DDR), DNA replication and chromatin organization though
complete characterization of these roles needs to be investigated in detail. It has important
tumour-suppressor functions and found to be highly mutated across a spectrum of cancers. Loss of
function mutations in Arid1a makes it challenging to treat these cancers leading to poor disease
prognosis in patients. Studies proposed here focus on the interplay between chromatin
organization, DNA damage and genome stability. More specifically, we aim to uncover the role of
Arid1a in regulating higher-order genome organization. The overarching goal of this project is
thus to understand the molecular mechanisms that underly genome organization and DNA damage
response mediated by Arid1a using genetics, biological, single molecule, and genomics approaches.
These questions proposed here will significantly broaden our understanding of the mechanisms
contributing to genome integrity and how breakdown in these processes contribute to
carcinogenesis and possible therapeutic resistance.
Place of Work: BRIC-NIBMG, Kalyani
Essential Education
1) Four years Bachelor's
Degree in Biological
Sciences
OR
Master's Degree in
Biological Sciences / BVSc
/В. Pharm
OR
Bachelor’s degree in
engineering or technology
or medicine from a
recognized University or
equivalent
2) Scholars have to be
selected through
i)National Eligibility Tests
- CSIR-UGC NET
including lectureship
(Assistant
Professorship) or GATE.
ii) National level
examinations conducted
by Govt. of India
Departments and their
Agencies and
Institutions such as DST,
DBT, DAE, DOS, DRDO,
MoE, ICAR, ICMR, IIT,
IISc, ISER, NISER etc.
Desirable Qualification
Experience in mammalian
cell culture and standard
molecular biology
techniques, including
DNA/RNA extraction, PCR,
qPCR, cloning, and protein
analysis.
Candidates having handson experience in
CRISPR/Cas9-mediated
genome editing, generation
and validation of stable cell
lines, and functional
characterization of cellular
phenotypes will be highly
desirable.
Prior experience in
genomics techniques such
as RNA-seq or related nextgeneration sequencing
(NGS)-based assays will be
highly desirable.
Experience with
sequencing library
preparation and quality
control of NGS samples will
be an added advantage.
Nature of work & Responsibilities The candidate will
be expected to plan
and execute
experiments,
analyze and
interpret
experimental data,
maintain proper
documentation of
research findings,
and actively
participate in
laboratory
discussions and
other research
activities as
assigned by the
Principal
Investigator.
The candidate
should
demonstrate
initiative in
learning new
methodologies,
troubleshooting
experiments, and
keeping abreast of
developments in
the field.
Consolidated and fixed monthly emolument
37,000+30%
HRA *
* If no suitable candidate is found then candidate may be given Rs. 30,000/- + 30% HRA for
others who do not fall under 2 (i-ii) above [Essential Education Qualification].
This position is contractual, and appointments will be initially for one year, which is extendable
depending upon performance and requirements of the project.
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