DuPont Recruits Scientists Biochemistry/Molecular Biology/Microbiology/Biotech

DuPont India

Hyderabad

Research Scientists (Principal Investigators) across following Disciplines:

1. Fermentation Sciences (Job Code:DKC-FS)

Strong background in biochemistry or microbial physiology (including primary and secondary metabolism), and will design, execute, and analyze fermentation experiments both at shake flask and fermentor level (continuous, fed-batch, and batch), to achieve microbe and process optimization goals. Requires experience and proficiency with various analytical techniques used for the fermentation physiology studies that include nutrients and metabolites extraction, isolation or monitoring. Knowledge of information management as it pertains to obtaining and sharing fermentation data is required. The successful candidate will also have demonstrated ability to a) design, execute, and analyze fermentation experiments (design of experiments), statistical design and data analysis for process optimization, and b) translate data from shake flask experiments to fermentor level studies. The successful candidate will be expected to maintain knowledge of the state-of-the-art in fermentation sciences and integrate that into DuPont programs where appropriate and to maintain expertise within multiple technologies in the areas of microbiology and metabolic engineering.

2. Protein Engineering, Enzymology ((Job Code:DKC-PE))

Protein engineering and enzymology experience with emphasis on biocatalyst identification, characterization, and optimization. The successful candidate will leverage biochemistry knowledge and bioinformatics tools, while working in teams, to develop biocatalytic routes for making chemicals and materials. Candidates should have a) robust knowledge of different types of biocatalytic mechanisms, and corresponding enzyme structure-function, b) proven experience in directed evolution / other protein optimization methods and / or screening diversity enzyme libraries, c) familiarity with software (SigmaPlot® or equivalent) for design and statistical analysis of kinetics data, and d) be well versed in spectroscopy, analytical techniques and quantitative enzyme kinetics. Able to suggest the pathway design strategy based on in vitro or in vivo enzyme kinetics and biochemical pathway data.

3. Microbial Chemistry / Biochemistry(Job Code:DKC-MB)

Chemistry/microbial biochemistry or relevant area with relevance to Industrial Biotechnology. Candidates must be proficient in a) microbial metabolic pathways (intermediary and secondary metabolism) and be able to elucidate/design new biochemical pathways for chemical or materials production leveraging bioinformatics, and literature data, including transport, biosynthesis, and energetics pathways, b) DOE to address production of a biomolecule in yeast or bacteria, c) have experience in using biochemical approaches to study gene regulation effect on intracellular protein or metabolite profiles, with applications to metabolic engineering and/or strain improvement, and d) experience in various analytical methods and assays.

4. Microbial Physiology / Metabolic Engineering (Job Code:DKC-ME)

The successful candidate is expected to have current knowledge in the field of metabolic engineering, be proficient in microbial physiology, metabolism, and/or metabolic flux analysis. Candidates should have prior experience in developing new pathways/strains (and models thereof) for yield improvement via identification of rate limiting steps, constructing new pathways for production of chemicals and materials from sustainable feedstocks and / or expressing recombinant genes / pathways.
Strain Development experience as applied to production of industrial chemicals from biobased routes, including random mutation/selection, and knowledge-based strain improvement. The candidate should have a) proven experience in any one / or more of industrially relevant microbial systems (bacteria, or yeast), with regards to improving protein/metabolite production, b) ability to establish innovative assays to screen overproducers and c) expertise in microbial genetics and genetically manipulating organisms for functional analysis and high level expression,

5. Molecular Microbiology, Strain Development (Job Code:DKC-SD)
Strain Development experience as applied to production of industrial chemicals from biobased routes, including random mutation/selection, and knowledge-based strain improvement. The candidate should have a) proven experience in any one / or more of industrially relevant microbial systems (bacteria, or yeast), with regards to improving protein/metabolite production, b) ability to establish innovative assays to screen overproducers and c) expertise in microbial genetics and genetically manipulating organisms for functional analysis and high level expression.

Qualifications

• -Ph.D. in Biochemistry/Chemistry, Enzymology, Molecular Biology, Microbiology, Microbial Physiology Chemical or Biochemical Engineering, Fermentation Sciences or related discipline with relevant experience as described for each position.
• -Two or more years of Post doctoral research experience preferred.
• -Demonstrated ability to supervise and develop research associates and deliver results in a team environment desired.

The successful candidates will be part of the Biochemical Sciences and Engineering group in Hyderabad and work as part of the greater DuPont community on global projects. The successful candidates will interact with a larger multidisciplinary group including microbial physiologists, enzymologists, molecular geneticists, and engineers in support of metabolic engineering and strain improvement programs within DuPont. The candidates should be self motivated, proactive communicators, and be able to establish good working relationships with all research teams and to thrive in a fast paced and global research environment.

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