Read this beautiful article from NATURE on Membrane Diseases.
Disruptions in the cytoskeleton can lead to a range of diseases, such as sickle cell anaemia and Duchenne muscular dystrophy (DMD). Sickle cell anaemia is a genetic disease that results in the production of a defective form of haemoglobin, which distorts red blood cells into the classic sickle shape. Red blood cells maintain their shape with a specialized cytoskeleton composed of a network of the proteins actin and spectrin. In sickle cell anaemia, this actin/spectrin lattice ‘locks’, making
red blood cells much less deformable, and causing them to obstruct the microcirculation.
helpBIOTECH’s CSIR Study Material also contains Extra info on Membrane Diseases.
More Details : http://helpbiotech.blogspot.in/2011/10/csir-study-material-life-sciences.html
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