We are hiring Team leader/ Senior Scientist to lead the downstream group
Adv No: BT/DSP/TL/26-2-2022
We are looking for Team leader/ Senior Scientist to lead the downstream group with expertise to support delivery (on time and within the budget) of developed purification processes of purified recombinant proteins. As a team leader he/she should be responsible to design, plan, develop, optimize and validate of chromatographic and downstream processes and should have extensive experience in Biopharmaceutical industry with biosimilar and/or peptide purification.
Overall Competency:
Able to develop scalable / robust chromatographic process and end-to-end downstream process
Experience in designing chromatographic purification methods for scalable process at R & D and pilot scale
Scouting and screening for suitable resins, buffer conditions and pH
Extensive experience with Ion-exchange, hydrophobic, RP-HPLC and other purification techniques
Method design, development, optimization, standardization, testing robustness and dynamic biding capacity measurement and validation
Familiarity with FPLC platforms like AKTA/ Unicorn and columns like XK, Hiscale, BPG and SS
Extensive experience with TFF, Hollowfibers, Ultrafiltration/ Diafiltration, Microfiltration techniques
Experience with Inclusion body preparation, solubilization and refolding is must
Perform in process contaminant profiling and impurity profiling
Experience in new method developments, troubleshooting, fixing specifications and in process controls
Deliver product specific and platform DSP documentation, process flow diagrams and reports ensuring appropriate quality of documentation to support inclusion of data and information in regulatory filings.
Documenting deviations and maintaining GDP in accordance with regulations and guidelines
Technology transfer of methods from R&D to manufacturing
Presentation of results at internal and external meetings
Represent the downstream group at regulatory inspections (during audits)
Ensuring a clean and organized protein lab environment
Ability to work independently as well as a member of a team in a dynamic environment
Train and mentor junior scientists or executives, providing scientific and technical expertise and guidance on downstream processing
Interact with other departments and teams involved within the company
Qualifications:
MSc with 10+ years of extensive knowledge and hands on experience in process development of protein purification and analysis
Or
PhD in Biochemistry/ Chemistry with 5+ years of experience in industry in operations and method designing
Interested candidates may apply to this position by sending their CV to careers@bycusbio.com
Please Quote the advertisement number in the subject of the e mail.
Lasst date 15th March 2022.
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